Safety of 222 nm UVC irradiation to the surgical site in a rabbit model
Safety of 222 nm UVC irradiation to the surgical site in a rabbit model The research group of Ushio, Inc. (Headquarters: Tokyo, President Koji Naito) and Department of Orthopedic Surgery, Graduate School of Medicine, Kobe University (Professor Ryosuke Kuroda, Associate Professor Takahiro Niikura, Assistant Professor Tomoaki Fukui) To investigate whether 222 nm UV radiation can be used to reduce intraoperative infections in the field of orthopedics, rabbits were used to irradiate five types of tissue that could be exposed to the surgical field with 222 nm or 254 nm UV radiation to immunize against DNA damage. We conducted an orthopedic evaluation. As a result, in the tissues collected 1 hour after UV irradiation, many CPDs (markers of UV-induced DNA damage) were found in each tissue in the 254 nm irradiation group, but in the 222 nm irradiation group, only adipose tissue was not irradiated. Although it increased with respect to the group, there was no significant difference from t...